Vascular Biology
Generation of out-of-body vascular systems to mimic the dynamic processes of angiogenesis and vasculogenesis
Vascular biology is one of the research areas where Santiagosic’s organ-on-a-chip platform has been widely used by numerous investigators in studying a variety of diseases, as indicated in the following publications. The platform has been optimized over the years to form robust vasculatures in a highly reproducible manner and its compartmented multi-channel structure is suited for culturing different cell types simultaneously, thus allowing their interactions with vasculatures. The chip can be used not only for performing a variety of endothelial cell assays with simple readouts but also for mimicking more complex disease states such as age-related macular degeneration (AMD) where both endothelial and non-endothelial cells contribute to the manifestation of pathology.
